There are many people who feel that they have nobody to talk to.
Even people close to them [who should be helping them] don’t seem to really understand them.
This may be a signal from Shamayim that Hashem wants to hear from him.
Many people have had major yeshuos by developing a close connection with Hashem, and speaking everything out to Him can cause great nissim.
—Bitachon Weekly for Parshat Nitzavim & Rosh Hashanah 5781
Furthermore, many people who empathize with others increasingly struggle with how to respond in the way most suitable for the person pouring out his heart.
They WANT to respond to the person's needs—but feel blocked from doing so, as if they're groping in the dark to reach the person in pain.
At the same time, a lot of people struggle to speak with Hashem (including people who happily spoke with Him regularly before—suddenly, they started feeling blocked).
Here's a genuinely helpful piece of advice from Rav Levi Yitzchak Bender:
Imagine Hashem as a best friend, a best friend who genuinely cares about you, a best friend who both can & wants to help you in any way possible.
(Because He really is this and more.)
Another tidbit of helpful advice:
Don't pressure yourself about the amount of time. (This advice comes from Rav Itamar Schwartz, among others.) Even 1 minute is excellent.
If you end up speaking for one minute, that's great. If that one minute turns into 5 minutes or 20 minutes or even 2 hours, then even better.
But that one minute of connection is great. Don't get caught up in the modern secular Edomite mentality that one minute doesn't matter, that it doesn't make a difference.